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  • Getting a good night’s sleep is given greater importance with the discovery that sleep deprivation appears to rapidly increase the spread of tau tangles.

Poor sleep has been associated with the development of Alzheimer's disease, and this has been thought to be in part because the protein amyloid beta increases with sleep deprivation. A new study explains more.

  • A short exercise program improved cognition and brain blood flow in older adults with mild cognitive impairment.

A small study has found that a 12-week exercise program significantly improved cognition in both older adults with

  • Preliminary research suggests that microbes in the gut directly affects dementia risk.

A Japanese study looking at 128 patients' fecal samples, found that fecal concentrations of ammonia, indole, skatole and phenol were higher in dementia patients compared to those without dementia, while levels of beneficial Bacteroides were lower in dementia patients.

  • A large clinical trial comparing the effects on cardiovascular disease of standard blood pressure control vs stricter control, has found that stricter control significantly reduced the risk of mild cognitive impairment.

A clinical trial involving 9361 older adults (50+) with hypertension but without diabetes or history of stroke has found that intensive control of blood pressure significantly reduced the risk of developing mild cognitive impairment.

  • A large Danish study has found that the greater number of symptoms of distress in late midlife, the more likely the individual was to develop dementia later in life.

Survey data from 6,807 Danish older adults (average age 60) in the Copenhagen City Heart Study, has found that being distressed in late midlife is associated with a higher risk of dementia in later life.

  • Older people who spend less time in slow-wave sleep (deep sleep) have higher levels of the Alzheimer’s brain protein tau.

Poor sleep has been associated with Alzheimer's disease risk, but a new study suggests a specific aspect of sleep is important.

  • A very large genetic study provides evidence that cardiovascular disease risk and Alzheimer's risk are related because of one shared element: genes involved in cholesterol and lipid metabolism.

The APOE gene, the strongest genetic risk factor for Alzheimer’s disease, is known to be involved in cholesterol and lipid metabolism.

  • Two large studies show an association between the Alzheimer's protein tau and the Alzheimer's gene APOE4, but the association varies across race and gender.

Data from 1,215 older adults, of whom 173 (14%) were African-American, has found that, although brain scans showed no significant differences between black and white participants,

  • More evidence comes from several studies of more subtle brain damage that isn't captured in conventional tests of concussions.
  • A new brainwave monitor finds brain impairments in ice hockey players that had been cleared to return to play after concussions, as well as signs of impairment from players experiencing sub-concussive impacts
  • A new way of analyzing brain images has found clear brain changes six months after female rugby players suffered concussions
  • Young adults suffering multiple concussions showed brainwave changes accompanied by poorer cognitive control more than a month after the last concussion
  • Detailed scans found hockey players cleared to return to play showed loosened myelin (the insulating substance around brain wiring)
  • However one study of young football players showed no association between sub-concussive impacts and neurocognitive performance (but were their tests sensitive enough?)

New method finds undetected brain impairments in ice hockey players with and without diagnosed concussions

  • The American Academy of Pediatrics (AAP) has updated its concussion recommendations.

The American Academy of Pediatric now supports children and teens engaging in light physical activity and returning to school as they recover. It also now advises against complete removal of electronic devices, such as television, computers and smartphones, following a concussion.

  • Two studies suggest that those with stronger and thicker necks, and those with a specific gene variant linked to dyslexia, are less vulnerable to concussion.
  • One study points to the value of good nights' sleep when recovering from concussion.

Can stronger necks reduce concussion risk & severity?

  • A very large dataset shows that a history of TBI significantly increases the risk of later dementia, with risk increasing for more injuries and more severe injuries.

A review of nearly 2.8 million patient cases in Denmark found that the risk of dementia in individuals with a history of TBI was 24% higher than those without a history of TBI, after accounting for other risk factors.

  • A small study finds strategy-based reasoning training has greater benefit for those with persistent TBI difficulties than a knowledge-based training program.

A study showing that a certain type of instructor-led brain training protocol can stimulate structural changes in the brain and neural connections even years after a traumatic brain injury (TBI) challenges the widely held belief that recovery from a TBI is limited to two years after an injury.

Key points that are new in the 5th International Consensus statement on concussion in sport:

  • A preliminary study suggests adults with persistent difficulties after TBI may benefit from a metacognitive training program in conjunction with use of Ritalin.

A small study involving 71 adults who struggled with persistent cognitive difficulties after suffering a traumatic brain injury at least four months before has compared two cognitive training programs with and without drug therapy.

The two six-week programs were

  • A large internet study has concluded that language-learning ability remains strong until about 17-18, however, to achieve native proficiency, you should start before age 10.

It’s long been speculated that there’s a critical period for learning a new language, but the specifics are a matter of debate. It is difficult to follow a sufficient number of language learners through their years of learning.

  • A small pilot study has confirmed that inflammation in the blood plays a role in chemobrain.

A pilot study involving 22 breast cancer patients currently receiving chemotherapy (mean age 54), has found that those with higher levels of inflammatory biomarkers did significantly worse on tests for short-term visual memory.

  • A small study has used older adults’ inability to ignore irrelevant information to improve their memory for face-name pairs.

One important reason for the greater cognitive problems commonly experienced as we age, is our increasing difficulty in ignoring distracting and irrelevant information. But it may be that in some circumstances that propensity can be used to help memory.

  • A study involving nearly 500 people with dementia has found that a rigorous physical exercise program did nothing to slow their decline.

A number of studies have found that physical exercise can help delay the onset of dementia, however the ability of exercise to slow the decline once dementia has set in is a more equivocal question. A large new study answers this question in the negative.

  • Brain imaging shows that musicians and bilinguals require less effort to perform an auditory working memory task, compared to monolingual non-musicians.

Musicians and people who are bilingual have long been shown to have a better

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