seniors

High-intensity exercise improves memory in seniors

  • A study found older adults (60+) who engaged in high-intensity interval training for 12 weeks showed significant memory improvement, while those engaging in moderate-intensity aerobic exercise did not.
  • A study involving young adults found greater fitness gains from HIIT were associated with greater increases in BDNF.

A study in which 64 sedentary older adults (aged 60-88) participated in a 12-week exercise program found that those who engaged in high-intensity interval training (HIIT) saw an improvement of up to 30% in memory performance while participants who engaged in moderate-intensity aerobic exercise saw no improvement, on average.

Moreover, improvements in fitness levels directly correlated with improvement in memory performance.

Participants participated in three sessions per week. A control group engaged in stretching only.

The HIIT protocol included four sets of high-intensity exercise on a treadmill for four minutes, followed by a recovery period. The MICT protocol included one set of moderate-intensity aerobic exercise for nearly 50 minutes.

Participants were assessed using a Mnemonic Similarity task and two tasks that assess executive function. The Mnemonic Similarity Task is highly sensitive to functions carried out by the hippocampus, which is the brain region most affected by exercise, through the creation of new neurons.

An earlier study involving 95 healthy young adults who underwent a 6 week HIIT program also showed significant improvements in this type of memory. Those who experienced greater fitness gains also experienced greater increases in brain-derived neurotrophic factor (BDNF).

Reference: 

Kovacevic, A., Fenesi, B., Paolucci, E., & Heisz, J. J. (2019). The effects of aerobic exercise intensity on memory in older adults. Applied Physiology, Nutrition, and Metabolism, 45(6), 591–600. https://doi.org/10.1139/apnm-2019-0495

Heisz, J. J., Clark, I. B., Bonin, K., Paolucci, E. M., Michalski, B., Becker, S., & Fahnestock, M. (2017). The Effects of Physical Exercise and Cognitive Training on Memory and Neurotrophic Factors. Journal of Cognitive Neuroscience, 29(11), 1895–1907. https://doi.org/10.1162/jocn_a_01164

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Improving fitness may counteract brain atrophy in older adults, including those with MCI

  • A small study involving physically inactive older adults found that a three-month exercise program reversed some brain atrophy.

A study involving 30 previously physically inactive older adults (aged 61-88) found that a three-month exercise program reversed some brain atrophy.

Participants included 14 with MCI. The exercise program included moderate intensity walking on a treadmill four times a week over a twelve-week period. On average, cardiorespiratory fitness improved by about 8% as a result of the training in both the healthy and MCI participants. Fitness was assessed using peak oxygen capacity rates.

Those who showed the greatest improvements in fitness had the most growth in cortical thickness. Those with MCI showed greater improvements compared to healthy group in the left insula and superior temporal gyrus, two brain regions that have been shown to exhibit accelerated neurodegeneration in Alzheimer’s disease.

Reference: 

Reiter, K., Nielson, K. A., Smith, T. J., Weiss, L. R., Alfini, A. J., & Smith, J. C. (2015). Improved Cardiorespiratory Fitness Is Associated with Increased Cortical Thickness in Mild Cognitive Impairment. Journal of the International Neuropsychological Society, 21(Special Issue 10), 757–767. https://doi.org/10.1017/S135561771500079X

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Exercise may be #1 way to prevent dementia

  • A long-running study involving women only found that regular exercise in middle age was the most effective they could do to prevent later cognitive decline.

A long-running study following 387 Australian women found that regular exercise in middle age was the best lifestyle change they could make to prevent cognitive decline in their later years.

The women were aged 45-55 when the study began in 1992. Health and lifestyle factors were assessed at intervals over the next 20 years.

Memory was assessed using a Verbal Episodic Memory test in which they were asked to learn a list of 10 unrelated words and attempt to recall them 30 minutes later.

Frequent physical activity, normal blood pressure, and high good cholesterol were all strongly associated with better recall, with regular exercise of any type emerging as the number one protective factor against memory loss.

The benefits of exercise were cumulative, meaning that every year’s activity counted. Similarly, the negative effects of high blood pressure were also cumulative. What you do over the course of your life, especially in middle age, matters! Which is not to say that’s a reason not make changes later in life. Better late than never definitely applies.

Reference: 

Szoeke, C., Lehert, P., Henderson, V. W., Dennerstein, L., Desmond, P., & Campbell, S. (2016). Predictive Factors for Verbal Memory Performance Over Decades of Aging: Data from the Women’s Healthy Ageing Project. The American Journal of Geriatric Psychiatry, 24(10), 857–867. https://doi.org/10.1016/j.jagp.2016.05.008

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Weak handgrip may warn of cognitive impairment

  • A large study finds weaker handgrip strength is associated with a progressively greater risk of developing severe cognitive impairment.
  • Another large long-running study similarly finds slow walking speeds and weak grip strength is associated with a greater risk of developing Alzheimer's disease.
  • Weaker grip strength, in those older than 65, was also linked to a higher risk of stroke.

A large study, involving nearly 14,000 older adults (50+) participating in the 2006 Health and Retirement Study, found that weaker handgrip strength was associated with a greater risk of developing cognitive impairment, especially severe impairment, over the eight-year study period.

Moreover, there was a dose-response type relationship, with every 5-kilogram (11-pound) reduction in handgrip strength being associated with a 10% greater risk of cognitive impairment and an 18% greater risk of severe cognitive impairment.

Handgrip strength was assessed with a hand-held dynamometer, and cognitive function with a modified Mini-Mental State Examination.

It’s suggested that reduced grip strength is associated with neural degeneration, but that maintaining your physical strength will protect you.

Data from the very long-running Framingham Heart Study also found that those who had slow walking speeds and weak grip strength had a significantly greater risk of developing Alzheimer’s disease in the next 11 years. Additionally, those older than 65 years had a higher risk of stroke if their hand grip strength was weak.

Participants were aged 35-84. Walking speed was assessed by walking a certain distance as fast as they could without running.

Reference: 

McGrath, R., Robinson-Lane, S. G., Cook, S., Clark, B. C., Herrmann, S., O’Connor, M. L., & Hackney, K. J. (2019). Handgrip Strength Is Associated with Poorer Cognitive Functioning in Aging Americans. Journal of Alzheimer’s Disease, 70(4), 1187–1196. https://doi.org/10.3233/JAD-190042

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Leafy greens slow cognitive decline

Data from the long-running Rush Memory and Aging Project, involving 960 participants who completed a food frequency questionnaire from 2004 to 2013, found that those who ate one daily serving of green, leafy vegetables had a slower rate of cognitive decline than people who rarely or never ate them. Those who ate at least one serving of leafy green vegetables showed an equivalent of being 11 years younger cognitively.

Participants had an average age of 81 at the beginning of the study. Analysis took into account such factors as seafood and alcohol consumption, smoking, high blood pressure, obesity, education level and amount of physical and cognitive activities.

Reference: 

Martha Clare Morris, Yamin Wang, Lisa L. Barnes, David A. Bennett, Bess Dawson-Hughes, Sarah L. Booth. Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study. Neurology Jan 2018, 90 (3) e214-e222; DOI: 10.1212/WNL.0000000000004815

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Fatty acids help the brain

A study involving 99 healthy older adults found that levels of monounsaturated fatty acids were associated with cognitive performance and the organization of the brain's attention network.

MUFAs are found in olive oils, nuts and avocados, and are a component of the Mediterranean diet, which has been associated with slower cognitive decline and lower dementia risk.

The study found that general intelligence was associated with how efficiently the dorsal attention network was functionally organized used a measure called small-world propensity, which describes how well the neural network is connected within locally clustered regions as well as across globally integrated systems.

In turn, they found that those with higher levels of MUFAs in their blood had greater small-world propensity in their dorsal attention network, suggesting that this is part of the reason for the link between diet and cognition.

And in another study by the same researchers, involving 94 older adults (65-75), blood levels of three omega-3 fatty acids (ALA, stearidonic acid and ecosatrienoic acid) were associated with levels of fluid intelligence, and this was mediated by the size of the left frontoparietal cortex. A larger left frontoparietal cortex was associated with higher levels of the omega-3 acids and better performance on tests of fluid intelligence.

A second study found that the size of a brain region called the fornix was associated with a balance of omega-3 and omega-6 fatty acids in the blood, and a more robust fornix was linked to better memory. The fornix is one of the first brain regions to be compromised in Alzheimer's disease.

Reference: 

Zamroziewicz, M. K., Talukdar, M. T., Zwilling, C. E., & Barbey, A. K. (2017). Nutritional status, brain network organization, and general intelligence. NeuroImage, 161, 241–250. https://doi.org/10.1016/j.neuroimage.2017.08.043

Zamroziewicz Marta K.,Paul Erick J.,Zwilling Chris E., et al. Predictors of Memory in Healthy Aging: Polyunsaturated Fatty Acid Balance and Fornix White Matter Integrity[J]. Aging and disease, 2017, 8(4): 372-383. http://www.aginganddisease.org/EN/10.14336/AD.2017.0501

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Stave off cognitive decline with seafood

Data from 915 older adults (mean age 81.4) participating in the very long-running Rush Memory and Aging Project, has found that those who reported eating seafood less than once a week showed greater cognitive decline compared to those who ate at least one seafood meal per week.

The food questionnaires included four types of seafood: tuna sandwiches; fish sticks, fish cakes and fish sandwiches; fresh fish as a main dish; and shrimp, lobster and crab. Those who ate at least one of those seafood meals per week ate an average of two seafood meals per week. Those and those who ate less than one of those seafood meals per week ate an average of 0.5 meals per week.

People who ate more seafood had better semantic memory and better perceptual speed (the ability to quickly compare letters, objects and patterns), but there wasn’t a significant difference in the rate of decline in episodic memory, working memory or visuospatial ability.

Factors such as education, physical activity, smoking and participating in mentally stimulating activities were taken into account in the analysis.

Interestingly, the protective association of seafood was stronger among those with the “Alzheimer’s gene” (APOE-ε4).

Reference: 

Ondine van de Rest, Yamin Wang, Lisa L. Barnes, Christine Tangney, David A. Bennett, Martha Clare Morris. APOEε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology May 2016, 86 (22) 2063-2070; DOI: 10.1212/WNL.0000000000002719

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Lots of fruit & veges helps older brains

Data from the Canadian Longitudinal Study on Aging, involving 8,574 middle-aged and older adults (aged 45-85), has found that those who ate more vegetables and fruits and more nuts and pulses (such as lentils and beans) scored higher on tests of verbal fluency. Every increase in average daily fruit and vegetable intake was linked to higher verbal fluency scores, but the best outcomes were found among those who consumed at least 6 servings a day.

Additionally, those with stage 2 hypertension had lower verbal fluency scores, as did those with higher levels of body fat.

Reference: 

Fuller-Thomson, E., Saab, Z., Davison, K. M., Lin, S. L., Taler, V., Kobayashi, K., & Tong, H. (2020). Nutrition, Immigration and Health Determinants are Linked to Verbal Fluency among Anglophone Adults in the Canadian Longitudinal Study on Aging (CLSA). The Journal of Nutrition, Health & Aging, 24(6), 672–680. https://doi.org/10.1007/s12603-020-1402-8

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Diet may help preserve cognitive function

Analysis of data from the Age-Related Eye Disease Study (AREDS) and AREDS2, involving a total of around 8,000 older adults, has found that those with the greatest adherence to the Mediterranean diet had the lowest risk of cognitive impairment. High fish and vegetable consumption appeared to have the greatest protective effect. At 10 years, AREDS2 participants with the highest fish consumption had the slowest rate of cognitive decline.

Those with the Alzheimer's gene ApoE4 on average had lower cognitive function scores and greater decline than those without the gene, but close adherence to a Mediterranean diet had similar benefits for people with and without the ApoE4 gene.

Reference: 

Keenan TD, Agron E, Mares J, Clemons TE, van Asten F, Swaroop A, and Chew E, for the AREDS and AREDS2 research groups. Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2. April 14, 2020. Alzheimer's and Dementia.

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