pesticides

Pesticide DDT linked to higher Alzheimer’s risk

A study comparing blood serum levels of the DDT metabolite, DDE, in 86 patients with Alzheimer's disease (average age 74) and 79 controls (average age 70), has found that levels of DDE were 3.8 times higher in 74 of the 86 Alzheimer’s patients (86%). Having the Alzheimer’s gene, APOe4, plus high levels of the pesticide, produced more severe cognitive impairment.

Brain cell studies found that DDE increased production of the amyloid precursor protein (APP).

DDT was banned in the U.S. in 1972, but is still used elsewhere. It also takes a long time to break down in the environment. DDE was found in 75-80% of blood samples collected from the Centers for Disease Control and Prevention for a national health and nutrition survey.

http://www.eurekalert.org/pub_releases/2014-01/usmc-rfe012914.php

http://www.futurity.org/ddt-exposure-linked-higher-alzheimers-risk/

Reference: 

[3602] Richardson, J. R., Roy A., SL S., & et al
(2014).  ELevated serum pesticide levels and risk for alzheimer disease.
JAMA Neurology. 71(3), 284 - 290.

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Cognition impaired by low-level exposure to organophosphate pesticides

January, 2013

A meta-analysis has concluded that low-level exposure to organophosphates has a small-to-moderate negative effect on cognitive function.

Organophosphate pesticides are the most widely used insecticides in the world; they are also (according to WHO), one of the most hazardous pesticides to vertebrate animals. While the toxic effects of high levels of organophosphates are well established, the effects of long-term low-level exposure are still controversial.

A meta-analysis involving 14 studies and more than 1,600 participants, reveals that the majority of well-designed studies undertaken over the last 20 years have found a significant association between low-level exposure to organophosphates and impaired cognitive function. Impairment was small to moderate, and mainly concerned psychomotor speed, executive function, visuospatial ability, working memory, and visual memory.

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