Some chronic viral infections could contribute to age-related cognitive decline

  • A longitudinal study confirms findings from cross-sectional studies that certain common viral infections are factors in age-related cognitive decline.

Growing research has implicated infections as a factor in age-related cognitive decline, but these have been cross-sectional (comparing different individuals, who will have a number of other, possibly confounding, attributes). Now a large longitudinal study provides more evidence that certain chronic viral infections could contribute to subtle cognitive deterioration in apparently healthy older adults.

The study involved 1,022 older adults (65+), who had annual evaluations for five years. It revealed an association between cognitive decline and exposure to several viruses: cytomegalovirus (CMV), herpes simplex (HSV 2), and the protozoa Toxoplasma gondii.

More specifically, the IgG levels for HSV-2 were significantly associated with baseline cognitive scores, while the IgG levels for HSV-2 (genital herpes), TOX (which has been much in the news in recent years for being harbored in domestic cats, and being implicated in various neurological disorders), and CMV (a common virus which unfortunately rarely causes symptoms), but not HSV-1 (the cold sore virus), were significantly associated with greater temporal cognitive decline that varied by type of infection.

More research is obviously needed to determine more precisely what the role of different infectious agents is in cognitive decline, but the findings do point to a need for a greater emphasis on preventing and treating infections. They also add to the growing evidence that age-related cognitive decline isn't 'normal', but something that occurs when other health-related factors come into play.

http://www.eurekalert.org/pub_releases/2016-02/uops-scv020416.php

Reference: 

Related News

A small UK study involving 28 healthy older adults (20 women with average age 70; 8 men with average age 67), has found that those with higher levels of aerobic fitness experienced fewer language failures such as 'tip-of-the-tongue' states.

Findings from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) Study, which followed 2,802 healthy older adults for 10 years, has found that those who participated in computer training designed to improve processing speed and visual attention had a 29% lower risk of dev

An Australian study involving 102 older adults (60-90) has concluded that physical fitness and arterial stiffness account for a great deal of age-related memory decline.

A long-running study involving 454 older adults who were given physical exams and cognitive tests every year for 20 years has found that those who moved more than average maintained more of their cognitive skills than people who were less active than average, even if they have brain lesions or b

Data from the English Longitudinal Study of Aging, in which nearly 4,000 older adults (60+) had their walking speed assessed on two occasions in 2002-2003 and in 2004-2005, those with a slower walking speed were more likely to develop dementia in the next 10 years.

Exercise activates brain networks in older adults

A study involving healthy older adults (55-85) found that recall was better after a session of moderately intense exercise, and several crucial brain regions showed greater activation.

Lowering blood pressure prevents worsening brain damage in elderly

A study involving 54 older adults (55-80), who possessed at least one risk factor for a stroke, found that those with

Perivascular spaces are fluid-filled spaces around the cerebral small vessels, commonly seen on brain scans in older adults. They have been thought to be harmless, but a new study challenges this belief.

Data from 3,105 older adults (65+) who had either heart surgery or cardiac catheterization has found that those who had heart surgery didn’t experience much greater cognitive decline compared with those who had the much less invasive, catheter-based procedure.

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news