Prenatal exposure to pesticides linked to attention problems

September, 2010

In a study of young Mexican-American children, higher prenatal exposure to pesticides was significantly associated with ADHD symptoms at age 5.

A study following over 300 Mexican-American children living in an agricultural community has found that their prenatal exposure to organophosphate pesticides (measured by metabolites in the mother’s urine during pregnancy) was significantly associated with attention problems at age 5. This association was stronger among boys, and stronger with age (at 3 ½ the association, although present, did not reach statistical significance — perhaps because attention disorders are much harder to recognize in toddlers). Based on maternal report, performance on attention tests, and a psychometrician’s report, 8.5% of 5-year-olds were classified as having ADHD symptoms. Each tenfold increase in prenatal pesticide metabolites was linked to having five times the odds of scoring high on the computerized tests at age 5. The child’s own level of phosphate metabolites was not linked with attention problems.

Organophosphate pesticides disrupt acetylcholine, which is important for attention and short-term memory. While the exposure of these children to pesticides is presumably higher and more chronic than that of the general U.S. population, food is a significant source of pesticide exposure among the general population.

Reference: 

Marks AR, Harley K, Bradman A, Kogut K, Barr DB, Johnson C, et al. 2010. Organophosphate Pesticide Exposure and Attention in Young Mexican-American Children. Environ Health Perspect :-. doi:10.1289/ehp.1002056
Full text available at http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3...

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