It is well known that the onset of puberty marks the end of the optimal period for learning language and certain spatial skills, such as computer/video game operation. A mouse study has now revealed that this is connected to an increase in a specific brain receptor (named Alpha4-Beta-Delta GABA-A). However, the learning deficit could be reversed by application of a stress steroid (THP). Although this natural hormone acts on adults like a tranquilizer, in adolescents it has a stimulation effect. The findings suggest that mild stress may be useful to improve learning in adolescents.
Reference:
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(2010). A Critical Role for {alpha}4{beta}{delta} GABAA Receptors in Shaping Learning Deficits at Puberty in Mice.
Science. 327(5972), 1515 - 1518.