HIV infection prematurely ages the brain

January, 2010

New evidence suggests that for that those with HIV, the disease, medications, or both, are accelerating what is a normal age-related process.

Although HIV doesn't directly infect neurons, it appears that once it has crossed the blood-brain barrier, it affects supporting cells that can release immune factors that harm neurons. New techniques used on 26 subjects with HIV and 25 matched controls have now found that those with HIV showed decreased brain blood flow to levels roughly equivalent to readings seen for uninfected individuals 15 to 20 years older. It is suggested that HIV, medications, or both, are accelerating what is a normal age-related process. It’s estimated that 14-18% of AIDS patients in the U.S. are more than 50 years old, and this proportion is rapidly growing.


Related News

Following on from a previous study showing that such a virtual supermarket game administered by a trained professional can detect

Data from the Women's Health Initiative Memory Study, involving 6,467 postmenopausal women (65+) who reported some level of caffeine consumption, has found that those who consumed above average amounts of coffee had a lower risk of developing dementia.

Our bodies’ ability to regulate its temperature gets worse with age, along with a slowing metabolism. We also become more vulnerable to Alzheimer's as we age. A study compared mice genetically engineered to manifest Alzheimer's symptoms as they age with normal mice.

People with Alzheimer's disease develop problems in recognizing familiar faces. It has been thought that this is just part of their general impairment, but a new study indicates that a specific, face-related impairment develops early in the disease.

Data from 876 patients (average age 78) in the 30-year Cardiovascular Health Study show that virtually any type of aerobic physical activity can improve brain volume and reduce Alzheimer's risk.

A study involving 100 older adults (aged 80-99) with hearing loss has found that those who used a hearing aid performed significantly better on a cognitive test (MMSE) than those who didn't use a hearing aid, despite having poorer hearing.

A study involving 65 older adults (average age 66), of whom 35 had type 2 diabetes, has found that after two years, those with diabetes had decreases in their ability to regulate blood flow in the brain, and a reduced ability to regulate blood flow was associated with lower cognitive scores.

A small study that fitted 29 young adults (18-31) and 31 older adults (55-82) with a device that recorded steps taken and the vigor and speed with which they were made, has found that those older adults with a higher step rate performed better on memory tasks than those who were more sedentary.

As we all know, people are living longer and obesity is at appalling levels. For both these (completely separate!) reasons, we expect to see growing rates of dementia. A new analysis using data from the long-running Framingham Heart Study offers some hope to individuals, however.

A study involving 39 older adults has found that those randomly assigned to a “high-challenge” group showed improved cognitive performance and more efficient brain activity compared with those assigned to a low-challenge group, or a control group.


Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health news