Latest Research News

A small study shows how those on the road to Alzheimer’s show early semantic problems long before memory problems arise, and that such problems can affect daily life.

There's quite a bit of evidence now that socializing — having frequent contact with others — helps protect against cognitive impairment in old age. We also know that depression is a risk factor for cognitive impairment and dementia. There have been hints that loneliness might also be a risk factor. But here’s the question: is it being alone, or feeling lonely, that is the danger?

A large Dutch study, following 2173 older adults for three years, suggests that it is the feeling of loneliness that is the main problem.

It’s always difficult in human studies to disentangle the effects of lifestyle factors. Alcohol is a case in point, and in particular the vexed question of whether any alcohol is safe during pregnancy. A new study, however, has avoided the complication of co-occurring lifestyle and environment factors by looking directly at genetic variants.

Problems with myelin — demyelination (seen most dramatically in MS, but also in other forms of neurodegeneration, including normal aging and depression); failure to develop sufficient myelin (in children and adolescents) — are increasingly being implicated in a wide range of disorders. A new animal study adds to that evidence by showing that social isolation brings about both depression and loss of myelin.

Sometime ago, I reported on a study showing that older adults could improve their memory for a future task (remembering to regularly test their blood sugar) by picturing themselves going through the process. Imagination has been shown to be a useful strategy in improving memory (and also motor skills). A new study extends and confirms previous findings, by testing free recall and comparing self-imagination to more traditional strategies.

There have been a number of studies in the past few years showing how poverty affects brain development and function. One of these showed specifically that children of high and low socioeconomic status showed differences in brain wave patterns associated with an auditory selective attention task. This was thought to indicate that the groups were using different mechanisms to carry out the task, with the lower SES children employing extra resources to attend to irrelevant information.

More evidence that even an 8-week meditation training program can have measurable effects on the brain comes from an imaging study. Moreover, the type of meditation makes a difference to how the brain changes.

The relative ease with which children acquire language has produced much debate and theory, mirroring the similar quantity of debate and theory over how we evolved language. One theory of language evolution is that it began with gesture. A recent study looking at how deaf children learn sign language might perhaps be taken as partial support for this theory, and may also have wider implications for how children acquire language and how we can best support them.

A review of 25 major studies investigating the value of sensory integration therapy (SIT) for autistic children has concluded that this most popular of therapies has no scientific support.

Only three of the 25 studies found benefits from SIT, and these three all had serious methodological flaws. Eight of the studies found mixed results, while 14 studies reported no benefits. Many of the reviewed studies had serious methodological flaws.

A study into how well students understand specific diagrams reminds us that, while pictures may be worth 1000 words, even small details can make a significant difference to how informative they are.

The study focused on variously formatted cladograms (also known as phylogenetic trees) that are commonly used in high school and college biology textbooks. Such diagrams are hierarchically branching, and are typically used to show the evolutionary history of taxa.

It’s been unclear whether hormone therapy helps older women reduce their risk of Alzheimer’s or in fact increases the risk. To date, the research has been inconsistent, with observational studies showing a reduced risk, and a large randomized controlled trial showed an increased risk. As mentioned before, the answer to the inconsistency may lie in the timing of the therapy. A new study supports this view.

In a large Mayo Clinic study, self-reported diet was found to be significantly associated with the risk of seniors developing mild cognitive impairment or dementia over a four-year period.

A study using data from the Lothian Birth Cohort (people born in Scotland in 1936) has analyzed brain scans of 638 participants when they were 73 years old. Comparing this data with participants’ earlier reports of their exercise and leisure activities at age 70, it was found that those who reported higher levels of regular physical activity showed significantly less brain atrophy than those who did minimal exercise. Participation in social and mentally stimulating activities, on the other hand, wasn’t associated with differences in brain atrophy.

Caffeine has been associated with a lower of developing Alzheimer's disease in some recent studies. A recent human study suggested that the reason lies in its effect on proteins involved in inflammation. A new mouse study provides more support for this idea.

Cancer survivors who underwent chemotherapy often suffer long-term cognitive problems. Until now, most research has been occupied with establishing that this is in fact the case, and studies investigating how to help have been rare. I recently reported on studies suggesting that help with sleep problems and stress can be beneficial. It has also been suggested that exercise can help.

We know that people with depression tend to focus on, and remember, negative memories rather than positive. Interestingly, it’s not simply an emotion effect. People with depression, and even those at risk of depression (including those who have had depression), tend to have trouble remembering specific autobiographical memories. That is, memories of events that happened to them at a specific place and time (as opposed to those generalized event memories we construct from similar events, such as the ‘going to the dentist’ memory).

The importance of early diagnosis for autism spectrum disorder has been highlighted by a recent study demonstrating the value of an educational program for toddlers with ASD.

The study involved 48 toddlers (18-30 months) diagnosed with autism and age-matched normally developing controls. Those with ASD were randomly assigned to participate in a two-year program called the Early Start Denver Model, or a standard community program.

Green tea is thought to have wide-ranging health benefits, especially in the prevention of cardiovascular disease, inflammatory diseases, and diabetes. These are all implicated in the development of age-related cognitive impairment, so it’s no surprise that regular drinking of green tea has been suggested as one way to help protect against age-related cognitive decline and dementia.

Like us, guinea pigs can’t make vitamin C, but must obtain it from their diet. This makes them a good model for examining the effects of vitamin C deficiency.

In my last report, I discussed a finding that intensive foreign language learning ‘grew’ the size of certain brain regions. This growth reflects gray matter increase. Another recent study looks at a different aspect:

A small Swedish brain imaging study adds to the evidence for the cognitive benefits of learning a new language by investigating the brain changes in students undergoing a highly intensive language course.

Stress is a major cause of workplace accidents, and most of us are only too familiar with the effects of acute stress on our thinking. However, although the cognitive effects are only too clear, research has had little understanding of how stress has this effect. A new rat study sheds some light.

I reported a few months ago on some evidence of a link between disturbed sleep and the development of Alzheimer’s. Now a mouse study adds to this evidence.

The mouse study follows on from an earlier study showing that brain levels of amyloid beta naturally rise when healthy young mice are awake and drop after they go to sleep, and that sleep deprivation disrupted this cycle and accelerated the development of amyloid plaques. This natural rhythm was confirmed in humans.

I’ve reported before on the growing evidence that metabolic syndrome in middle and old age is linked to greater risk of cognitive impairment in old age and faster decline. A new study shows at least part of the reason.

We know that stress has a complicated relationship with learning, but in general its effect is negative, and part of that is due to stress producing anxious thoughts that clog up

Memory problems in those with mild cognitive impairment may begin with problems in visual discrimination and vulnerability to interference — a hopeful discovery in that interventions to improve discriminability and reduce interference may have a flow-on effect to cognition.

Back in 2010, I briefly reported on a study suggesting that a few minutes of ‘quiet time’ could help you consolidate new information. A new study provides more support for this idea.

Here’s an exciting little study, implying as it does that one particular aspect of information processing underlies much of the cognitive decline in older adults, and that this can be improved through training. No, it’s not our usual suspect,

HIV-associated dementia occurs in around 30% of untreated HIV-positive patients. Surprisingly, it also is occasionally found in some patients (2-3%) who are being successfully treated for HIV (and show no signs of AIDS).

A new study may have the answer for this mystery, and suggest a solution. Moreover, the answer may have general implications for those experiencing cognitive decline in old age.

Spatial abilities have been shown to be important for achievement in STEM subjects (science, technology, engineering, math), but many people have felt that spatial skills are something you’re either born with or not.

I’ve reported, often, on the evidence that multitasking is a problem, something we’re not really designed to do well (with the exception of a few fortunate individuals), and that the problem is rooted in our extremely limited

What underlies differences in fluid intelligence? How are smart brains different from those that are merely ‘average’?

Brain imaging studies have pointed to several aspects. One is brain size. Although the history of simplistic comparisons of brain size has been turbulent (you cannot, for example, directly compare brain size without taking into account the size of the body it’s part of), nevertheless, overall brain size does count for something — 6.7% of individual variation in intelligence, it’s estimated. So, something, but not a huge amount.

My recent reports on brain training for older adults (see, e.g., Review of working memory training programs finds no broader benefit; Cognitive training shown to help healthy older adults; Video game training benefits cognition in some older adults) converge on the idea that cognitive training can indeed be beneficial for older adults

Genetic comparisons have pinpointed a specific protein as crucial for brain size, both between and within species. Another shows how genetic regulation in the frontal

Back in 2009, I reported briefly on a large Norwegian study that found that older adults who consumed chocolate, wine, and tea performed significantly better on cognitive tests. The association was assumed to be linked to the flavanols in these products. A new study confirms this finding, and extends it to older adults with mild cognitive impairment.

Two years ago, I reported on a clinical trial of a nutrient cocktail called Souvenaid for those with early Alzheimer’s. The three-month trial, involving 225 patients, had some success in improving verbal recall, with those with the mildest level of impairment benefiting the most.

In the light of a general increase in caesarean sections, it’s somewhat alarming to read about a mouse study that found that vaginal birth triggers the expression of a protein in the brains of newborns that improves brain development, and this protein expression is impaired in the brains of those delivered by C-section.

Adding to the growing evidence for the long-term cognitive benefits of childhood music training, a new study has found that even a few years of music training in childhood has long-lasting benefits for auditory discrimination.

Our life-experiences contain a wealth of new and old information. The relative proportions of these change, of course, as we age. But how do we know whether we should be encoding new information or retrieving old information? It’s easy if the information is readily accessible, but what if it’s not? Bear in mind that (especially as we get older) most information / experiences we meet share some similarity to information we already have.


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