Latest Research News

A study involving both mice and human cells adds to evidence that stress is a risk factor for Alzheimer's.

The study found that mice who were subjected to acute stress had more amyloid-beta protein in their brains than a control group. Moreover, they had more of a specific form of the protein, one that has a particularly pernicious role in the development of Alzheimer's disease.

Data from 23,572 Americans from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study has revealed that those who survived a stroke went on to have significantly faster rates of cognitive decline as they aged.

Participants, who were aged 45 years or older, had no history of cognitive impairment at the beginning of the population-based study. Over the next five to seven years, 515 of them (2%) had a stroke.

A study involving 382 older adults (average age 75) followed for around five years, has found that those who don’t get enough vitamin D may experience cognitive decline at a much faster rate than people who have adequate vitamin D.

A study involving older adults has found that diabetes was associated with higher levels of tau protein and greater brain atrophy.

The study involved 816 older adults (average age 74), of whom 397 had mild cognitive impairment, 191 had Alzheimer's disease, and 228 people had no cognitive problems. Fifteen percent (124) had diabetes.

Those with diabetes had greater levels of tau protein in the spinal and brain fluid regardless of cognitive status. Tau tangles are characteristic of Alzheimer's.

Training in a mental imagery technique has been found to help multiple sclerosis patients in two memory domains often affected by the disease: autobiographical memory and episodic future thinking.

Data from 1,895 fourth and fifth grade children living in El Paso, Texas has found that those who were exposed to high levels of motor vehicle emissions had significantly lower GPAs, even when accounting for other factors known to influence school performance.

The link between air pollution and academic performance may be direct (pollutants damage the brain) or indirect — through illness and absenteeism.

The finding adds to other evidence linking air pollution around schools to children's academic performance.

A study involving 218 participants aged 18-88 has looked at the effects of age on the brain activity of participants viewing an edited version of a 1961 Hitchcock TV episode (given that participants viewed the movie while in a MRI machine, the 25 minute episode was condensed to 8 minutes).

While many studies have looked at how age changes brain function, the stimuli used have typically been quite simple. This thriller-type story provides more complex and naturalistic stimuli.

A study involving 100 healthy older adults (aged 60-80) has found that those with higher levels of physical activity showed more variable spontaneous brain activity in certain brain regions (including the precuneus,

A ten-year study involving 2,092 older adults (average age 76) has found that people tended to lose awareness of memory problems two to three years before the onset of dementia.

Being unaware of your own memory problems is common in dementia, but previous research has focused on those already diagnosed with dementia. In this study, participants had no cognitive impairment at the beginning of the study.

A large, five-year study challenges the idea that omega-3 fatty acids can slow age-related cognitive decline. The study, involving 4,000 older adults, was part of the Age-Related Eye Disease Study (AREDS), which established that daily high doses of certain antioxidants and minerals can help slow the progression of age-related macular degeneration. However, a follow-up study found the addition of omega-3 fatty acids to the AREDS formula made no difference.

A large, two-year study challenges the evidence that regular exercise helps prevent age-related cognitive decline.

The study involved 1,635 older adults (70-89) who were enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. They were sedentary adults who were at risk for mobility disability but able to walk about a quarter mile. Participants had no significant cognitive impairment (as measured by the MMSE) at the beginning of the study. Around 90% (1476) made it to the end of the study, and were included in the analysis.

A small study using an artificial language adds to evidence that new vocabulary is learned more easily when the learner uses gestures.

“Vimmish”, the artificial language used in the study, follows similar phonetic rules to Italian. The German-speaking participants were given abstract and concrete nouns to learn over the course of a week. In the first experiment, the 21 subjects heard the words and their translations under one of three conditions:

A new questionnaire has been developed that very quickly determines whether or not a person has dementia and whether it's very mild, mild, moderate or severe. The 10-item questionnaire takes only 3-5 minutes and can be completed by a caregiver, friend or family member.

Testing on 239 individuals with various forms of dementia and 28 healthy controls has shown the results are comparable to the gold standard used presently, which takes several hours for an experienced professional to administer, interpret and score.

A study of 438 first- and second-grade students and their primary caregivers has revealed that parents' math anxiety affects their children's math performance — but (and this is the surprising bit) only when they frequently help them with their math homework.

The study builds on previous research showing that students learn less math when their teachers are anxious about math. This is not particularly surprising, and it wouldn't have been surprising if this study had found that math-anxious parents had math-anxious children. But the story wasn't that simple.

A small study that compared teaching Spanish-speaking children English vocabulary using a song or a spoken poem has found definite and long-term advantages to the song form.

A meta-analysis of studies reporting brain activity in individuals with a diagnosis of PTSD has revealed differences between the brain activity of individuals with PTSD and that of groups of both trauma-exposed (those who had experienced trauma but didn't have a diagnosis of PTSD) and trauma-naïve (those who hadn't experienced trauma) participants.

I've written at length about implementation plans in my book “Planning to Remember: How to Remember What You're Doing and What You Plan to Do”. Essentially, they're intentions you make in which you explicitly tie together your intended action with a specific situational cue (such as seeing a post box).

More evidence for the benefits of the Mediterranean diet for fighting age-related cognitive decline comes from a large 5-year study. The study involved 960 older adults, whose cognitive change was assessed over 4.7 years. Those who followed the MIND diet more rigorously showed an equivalent of being 7.5 years younger cognitively than those who followed the diet least.

The Mediterranean-DASH Diet Intervention for Neurodegenerative Delay is a hybrid of the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets. It requires at least:

This sounds like pseudoscience, but it appears in Journal of Neuroscience, so … Weirdly, a rat study has found that sleeping on the side (the most common posture for humans and other animals) is the best position for efficiently removing waste from the brain.

A long-running study comparing African-Americans and Nigerians has found the incidence of dementia has fallen significantly over two decades among the African-Americans, but remained the same for the Nigerians (for whom it was lower anyway).

The study enrolled two cohorts, one in 1992 and one in 2001, who were evaluated every 2–3 years until 2009. The 1992 cohort included 1440 older African-Americans (70+) and 1774 Nigerian Yoruba; the 2001 cohort included 1835 African-Americans and 1895 Yoruba. None of the participants had dementia at study beginning.

A post-mortem study of five Alzheimer's and five control brains has revealed the presence of iron-containing microglia in the subiculum of the Alzheimer's brains only.

We've seen a number of studies showing the value of music training for children's development of language skills. A new study has investigated what happens if the training doesn't begin until high school.

Cognitive impairment affects 40-65% of people with MS. Why? In the past year, a number of studies have helped us build a better picture of the precise nature of cognitive problems that may affect multiple sclerosis sufferers:

There's been a lot of talk in recent years about the importance of mindset in learning, with those who have a “growth mindset” (ie believe that intelligence can be developed) being more academically successful than those who believe that intelligence is a fixed attribute. A new study shows that a 45-minute online intervention can help struggling high school students.

This is just a preliminary study presented at a recent conference, so we can't give it too much weight, but the finding is consistent with what we know about

Because this is such a persistent myth, I thought I should briefly report on this massive study that should hopefully put an end to this myth once and for all (I wish! Myths are not so easily squashed.)

This study used data from 377,000 U.S. high school students, and, agreeing with a previous large study, found that first-borns have a one IQ point advantage over later-born siblings, but while statistically significant, this is a difference of no practical significance.

Blood pressure data from 378 participants in the Framingham Heart Study has revealed that those who had high systolic blood pressure when they were 50-60 years old scored worse on a

A six-month pilot study involving 101 healthy older adults (65+), who were randomly put into one of three exercise interventions or a no-change control, has found that the exercise groups all showed significant improvement in visual-spatial processing and attention, with more improvement in visual-spatial processing occurring in those with higher levels of exercise.

I've reported before on the idea that the drop in

A six-week study involving 619 cancer patients has found that those who took part in a simple home-based exercise program significantly reduced their cognitive impairment ('chemo-brain'). The EXCAP (Exercise for Cancer Patients) was developed by the researchers some years ago, and this evaluation was a phase III randomized study for early-stage chemotherapy patients. Half the group were given standard care (no exercise during chemotherapy), while the others were given instruction to walk daily and carry out low-to-moderate resistance band training for 10 minutes, 5 days a week.

A small study involving 50 children and teens living in Mexico City (aged 13.4 ± 4.8 years) has found that those with the 'Alzheimer's gene' APOEε4 (22 of the 50) were more vulnerable to the effects of air pollution on cognition. Those with the gene variant had a reduced NAA/Cr ratio in the right frontal

Alzheimer's the evolutionary cost of better brains?

An examination of the brains of three groups of deceased individuals (13 cognitively normal, aged 20-66; 16 non-demented older adults, aged 70-99; 21 individuals with Alzheimer's, aged 60-95) has found that amyloid starts to accumulate and clump inside basal

A large meta-analysis has concluded that having diabetes increases the chance that a person with mild cognitive impairment will progress to dementia by 65%.

A review and a large study have recently added to the growing evidence that type 2 diabetes is not only a risk factor for Alzheimer's, but is also linked to poorer cognitive function and faster age-related cognitive decline. The amount of this also seems to be related to glucose control in a dose-dependent manner.

Last year I reported on a finding that ten lipids in the blood could predict development of MCI or Alzheimer's within 2-3 years, with over 90% accuracy.

A review of meditation research reported in January last year concluded that there were insufficient good studies to allow us to say that meditation clearly improves attention and cognition. Studies from 2014 suggest three factors that might be part of the reason for inconsistent research findings:

In 2013 I reported briefly on a pilot study showing that “super-agers” — those over 80 years old who have the brains and cognitive powers more typical of people decades younger — had an unusually large

In 2013 I reported how a 3-second interruption while doing a task doubled the rate of sequence errors, while a 4s one tripled it. A new study has attempted to measure just how much ongoing interruptions can negatively affect the quality of a complex creative task.

Three recent studies point to the impact of social media and multiple device use on learning and cognitive control.

College students take years to learn to manage their social media so it doesn't impact their grades

A survey of 1,649 college students has found that freshmen average a total of two hours a day on Facebook, of which over an hour is spent also doing schoolwork, and that time spent on Facebook had a negative impact on their grade point average. For sophomores and juniors, only time spent using Facebook while doing schoolwork affected their GPA.

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