Alzheimer's gene linked to red wine component

A new discovery helps explain why the “Alzheimer’s gene” ApoE4 is such a risk factor. It appears that ApoE4 causes a dramatic reduction in SirT1, an "anti-aging protein" that is targeted by resveratrol (present in red wine). This reduction in SirT1 was associated with a change in the way the amyloid precursor protein (APP) was processed. Moreover, there was evidence that ‘bad’ tau and amyloid-beta could be prevented by increasing SirT1.

http://www.eurekalert.org/pub_releases/2013-10/bifa-mar101613.php

[3611] Theendakara V, Patent A, Libeu CPA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, et al. Neuroprotective Sirtuin ratio reversed by ApoE4. Proceedings of the National Academy of Sciences [Internet]. 2013 ;110(45):18303 - 18308. Available from: http://www.pnas.org/content/110/45/18303

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