- beta-amyloid plaques
are considered one of the hallmarks of Alzheimer's disease. The plaques are hard, insoluble aggregations of various peptides and proteins, chiefly and most important amyloid-beta peptides. Recent research suggests plaques attach primarily to blood vessels, damaging them.
one of three forms of secretase, it and gamma-secretase are implicated in the formation of plaques.
- brain-derived neurotrophic factor
a neuropeptide important for neuronal growth, survival, differentiation, connectivity and synaptic plasticity. The gene controlling BDNF expression comes in two variants, one of which is linked to poorer memory.
Glossary of neurological terms
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