Alzheimer's & Other Dementias

Research Topics

Latest news

Cholesterol genes link risk of heart disease & Alzheimer’s
  • A very large genetic study provides evidence that cardiovascular disease risk and Alzheimer's risk are related because of one shared element: genes involved in cholesterol and lipid metabolism.

The APOE gene, the strongest genetic risk factor for Alzheimer’s disease, is known to be involved in cholesterol and lipid metabolism.
Lower tau levels may obscure early Alzheimer’s in black patients
  • Two large studies show an association between the Alzheimer's protein tau and the Alzheimer's gene APOE4, but the association varies across race and gender.

Data from 1,215 older adults, of whom 173 (14%) were African-American, has found that, although brain scans showed no significant differences between black and white participants,

Rigorous exercise does not slow dementia decline
  • A study involving nearly 500 people with dementia has found that a rigorous physical exercise program did nothing to slow their decline.

A number of studies have found that physical exercise can help delay the onset of dementia, however the ability of exercise to slow the decline once dementia has set in is a more equivocal question. A large new study answers this question in the negative.
Reduced face memorization ability in those with MCI
  • A small study suggests that the ability to remember faces specifically is impaired in those with amnestic mild cognitive impairment.

A small Japanese study has found evidence that those with amnestic mild cognitive impairment (aMCI) show a specific decline in their ability to recognize faces, and this is accompanied by changes in the way they scan faces.
Personality changes during transition to MCI
  • Behavioral and personality changes seen in those with Alzheimer's appear to be reflected in very early increases in neuroticism and declines in openness.

Mild cognitive impairment (
Dementia trend shows later onset with fewer years of the disease
  • A large study shows that the falling rates of dementia reflect later onset coupled with shorter time spent with the dementia.

A large study using data from the famous Framingham Heart Study has compared changes in dementia onset over the last three decades. The study found that over time the age of onset has increased while the length of time spent with dementia has decreased.
Rapid blood pressure drops in middle age linked to dementia in old age
  • A large study indicates that an inclination to dizziness on standing up is associated with a greater risk of developing cognitive impairment and dementia decades later.

Data from over 11,500 participants in the Atherosclerosis Risk in Communities (ARIC) cohort has found evidence that orthostatic hypotension in middle age may increase the risk of cognitive impairment and dementia 20 years later.
Brain proteins involved in the development of Alzheimer's
  • When a particular fat molecule in the brain doesn't break down properly, cognition gets harder, and there's an increase in amyloid precursor proteins (which are part of the Alzheimer's cascade).
  • Tau proteins are also involved in the Alzheimer's cascade. A new study shows that individuals vary markedly in how quickly they spread in the brain.
  • A protein called SIRT6 has now been found to be crucially involved in DNA repair, to be severely deficient in those with Alzheimer's, and to be associated with learning impairment in mice.
  • A protein called NPTX2 may explain why some brains can cope with high levels of amyloid-beta much better than others.

Disrupted fat breakdown in the brain involved in Alzheimer’s?
Spatial impairment early sign of Alzheimer’s
  • A cognitive test has been shown to identify early shrinking of the brain region first affected by Alzheimer's.

A Canadian study involving 40 older adults (59-81), none of whom were aware of any major memory problems, has found that those scoring below 26 on the Montreal Cognitive Assessment (MoCA) dementia screening test also showed shrinking of the anterolateral

Aerobic exercise preserves brain volume and improves cognition in those with MCI
  • Regular exercise has been found to reduce brain shrinkage in those with mild cognitive impairment.

A study involving 35 adults with

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