Alzheimer's Disease

Poorer sleep linked to Alzheimer plaques

Data from 70 older adults (average age 76) in the Baltimore Longitudinal Study of Aging has found that those who reported poorer sleep (shorter sleep duration and lower sleep quality) showed a greater buildup of amyloid-beta plaques.

http://www.eurekalert.org/pub_releases/2013-10/tjnj-lsa101813.php

Mynd: 

tags development: 

tags lifestyle: 

tags problems: 

Alzheimer's gene linked to red wine component

A new discovery helps explain why the “Alzheimer’s gene” ApoE4 is such a risk factor. It appears that ApoE4 causes a dramatic reduction in SirT1, an "anti-aging protein" that is targeted by resveratrol (present in red wine).

Mynd: 

tags: 

tags development: 

tags lifestyle: 

tags memworks: 

tags problems: 

Impaired recovery from inflammation linked to Alzheimer's

Analyses of cerebrospinal fluid from 15 patients with Alzheimer's disease, 20 patients with mild cognitive impairment, and 21 control subjects, plus brain tissue from some of them, has found that those with Alzheimer’s had lower levels of a particular molecule involved in resolving inflammation. These ‘specialized pro-resolving mediators’ regulate the tidying up of the damage done by inflammation and the release of growth factors that stimulate tissue repair.

Mynd: 

tags development: 

tags lifestyle: 

tags problems: 

Why sleep is disrupted in Alzheimer's disease

A study involving genetically engineered fruit flies adds to our understanding of why sleep and bioclock disruptions are common in those with Alzheimer's disease. People with Alzheimer's often have poor biological rhythms — periods of sleep become shorter and more fragmented, resulting in periods of wakefulness at night and snoozing during the day. It has been thought that Alzheimer’s destroys the biological clock, but this new study indicates that the clock is still working — however, it’s being ignored by other parts of the brain.

Mynd: 

tags development: 

tags lifestyle: 

tags problems: 

How inflammation and hypoxia damage the brain

A new study shows that a combination of inflammation and hypoxia activates microglia in a way that persistently weakens the connection between neurons, contributing to brain damage in conditions such as stroke and Alzheimer's disease.

http://www.eurekalert.org/pub_releases/2014-03/uobc-scb031214.php

Mynd: 

tags: 

tags development: 

tags problems: 

Down Syndrome risk of Alzheimer’s connected to white matter integrity

Brain scans of 10 persons with Down syndrome but no dementia, 10 persons with Down syndrome and dementia, and 10 healthy controls, have revealed a linear correlation between cognitive ability and compromised

Mynd: 

tags problems: 

Prion proteins might help reduce amyloid-beta plaques

New research helps explain the role of amyloid-beta plaques in the development of Alzheimer's, by finding that the prion protein known to bind strongly to small aggregates of amyloid-beta peptides, also attaches to large fibrillar clumps of amyloid-beta.

Mynd: 

tags development: 

tags problems: 

Pages

Subscribe to RSS - Alzheimer's Disease