mGluR5

a glutamate receptor, an excess of which has been implicated in Fragile X syndrome. Fragile X, the leading cause of mental retardation, is characterized by loss of the FMR1 gene, which encodes the fragile X mental retardation protein (FMRP). FMRP and mGluR5 keep each other in check; without FMRP, mGluR5 increase excessively.

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