are tangled bundles of fibers inside neurons. Like plaques, they are considered one of the hallmarks of Alzheimer's disease, although they also occur in other neurological disorders. Tangles mainly consist of tau protein. By disrupting the structure of the neuron and disabling the transport of nutrients, tangles cause neurons to die. Plaques can induce tangles, but that is only one way in which tangles can form. Nicotine is, apparently, another.
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