is characterized by symptoms appearing before age 65; it is thankfully rare (some 6-8% of Alzheimer's cases are early-onset). Early-onset Alzheimer's has a much stronger genetic basis that late-onset Alzheimer's, and is therefore also known as familial Alzheimer's. Three genes have been implicated, on chromosomes 1, 14 and 21 (see presenilins). Any one of these will almost certainly lead to early-onset Alzheimer's. Early-onset Alzheimer's can begin as early as the 30s or 40s but that is exceedingly rare; more usually it begins in the 50s.
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