are a group of lipid-signaling molecules implicated in programmed cell death. Ceramide can stimulate growth or bring about cell death; which of these occurs is determined by contextual factors. Ceramide content is significantly increased in skeletal muscle in insulin-resistant obese humans. Ceramides have been implicated in ischemic stroke and Parkinson's. Ceramide content is high in the white matter of those with Alzheimer's, peaking at the stage of very mild dementia.
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